Only PENTASA® delivers 5-ASA from top to bottom

PENTASA moisture-activated microspheres ensure reliable delivery throughout the small and large intestine1-5

  • Release of 5-ASA from PENTASA is independent of pH.
  • The moisture-activated MOA ensures that PENTASA will begin delivering mesalamine in the duodenum.6
  • 5-ASA is released at a virtually constant rate from the duodenum to the rectum, until essentially all the available drug is delivered1,2,6,7

Moisture-activated PENTASA provides complete top-to-bottom coverage

  • Only moisture-activated, controlled-release PENTASA delivers 5-ASA to the duodenum, jejunum, ileum, terminal ileum, proximal colon, distal colon, and rectum. 6,7

Other 5-ASA products deliver to limited areas of the intestine

  • pH-dependent, delayed-release Asacol delivers 5-ASA only to the distal ileum, colon and rectum.7
  • Colazal delivers 5-ASA to the colon following bacterial cleavage of the azo bond.6,12

Next: Dosing

Asacol® is a registered trademark of Procter & Gamble Pharmaceuticals.

Colazal® is a registered trademark of Salix Pharmaceuticals.

PENTASA moisture-activated microspheres ensure reliable delivery throughout the small and large intestine (1-5)

Moisture-activated PENTASA provides complete top-to-bottom coverage

Important Safety Information

  • PENTASA is indicated for the induction of remission and for the treatment of patients with mildly to moderately active ulcerative colitis.
  • PENTASA is generally well tolerated. In worldwide clinical trials (N>2100), the most common adverse events were diarrhea (3.4%), headache (2.0%), nausea (1.8%), abdominal pain (1.7%), dyspepsia (1.6%), vomiting (1.5%), and rash (1.0%). As with other mesalamine products, serious adverse events may occur. PENTASA is contraindicated in patients with a hypersensitivity to salicylates. Caution should be used in patients with impaired hepatic or renal function. Patients with pre-existing renal disease, increased BUN or serum creatinine, or proteinuria should be monitored during PENTASA therapy.