Contact Us

Thank you for your interest in PENTASA® and Shire US Inc. We welcome your comments and questions.

U.S. Headquarters

Shire US Inc.
725 Chesterbrook Blvd.
Wayne, PA 19087-5367
Toll free: (800) 828-2088

Patients and Caregivers

Call the Shire Customer Service Center toll free at 1-800-828-2088, M-F 8:30 AM -5:30 PM EST.

Healthcare Professionals

Clinical inquiries: For further clinical information on Shire products, U.S. healthcare professionals may call toll free at 1-800-828-2088 or e-mail MedInfoGlobal@Shire.com

PENTASA Patient Assistance Program: Physicians or their representatives who would like to enroll patients in the PENTASA Patient Assistance Program may call 866-325-8224 for enrollment applications and additional information, or view and download a brochure and application by clicking here

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Please see Important Safety Information and Full Prescribing Information for details about PENTASA®.

Important Safety Information

  • PENTASA is indicated for the induction of remission and for the treatment of patients with mildly to moderately active ulcerative colitis.
  • PENTASA is generally well tolerated. In worldwide clinical trials (N>2100), the most common adverse events were diarrhea (3.4%), headache (2.0%), nausea (1.8%), abdominal pain (1.7%), dyspepsia (1.6%), vomiting (1.5%), and rash (1.0%). As with other mesalamine products, serious adverse events may occur. PENTASA is contraindicated in patients with a hypersensitivity to salicylates. Caution should be used in patients with impaired hepatic or renal function. Patients with pre-existing renal disease, increased BUN or serum creatinine, or proteinuria should be monitored during PENTASA therapy.