Contact Us
Thank you for your interest in PENTASA and Shire US Inc. We welcome your comments and questions.
US Headquarters
Shire US Inc.
725 Chesterbrook Blvd
Wayne, PA 19087
Toll free: (800) 828-2088
Patients and Caregivers
Call the Shire Customer Service Center toll free at 1-800-828-2088, M-F 8:30 AM -5:30 PM ET.
Health Care Professionals
Clinical inquiries: For further clinical information on Shire products, US health care professionals may call toll free at 1-800-828-2088 or e-mail MedInfoGlobal@Shire.com
PENTASA Patient Assistance Program: Physicians or their representatives who would like to enroll patients in the PENTASA Patient Assistance Program may call 866-325-8224 for enrollment applications and additional information, or view and download an application by clicking here 
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Please see Important Safety Information and Full Prescribing Information for details about PENTASA.
Important Safety Information
- PENTASA is indicated for the induction of remission and for the treatment of patients with mildly to moderately active ulcerative colitis.
- PENTASA is generally well tolerated. In worldwide clinical trials (N>2100), the most common adverse events were diarrhea (3.4%), headache (2.0%), nausea (1.8%), abdominal pain (1.7%), dyspepsia (1.6%), vomiting (1.5%), and rash (1.0%). As with other mesalamine products, serious adverse events may occur. PENTASA is contraindicated in patients with a hypersensitivity to salicylates. Caution should be used in patients with impaired hepatic or renal function. Patients with pre-existing renal disease, increased BUN or serum creatinine, or proteinuria should be monitored during PENTASA therapy.